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学科带头人-韩骅教授


更新时间:2010-04-20



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韩骅,男,1961年9月出生,1991年于第四军医大学获医学博士学位,先后在日本京都大学医学部医化学教室留学和进行客座研究8年,并获博士学位。现任第四军医大学医学遗传学与发育生物学教研室教授、主任、博士研究生导师。中华医学会医学遗传学分会委员,陕西医学遗传学会副主委;中国生物化学与分子生物学学会陕西分会常务理事;《国际遗传学杂志》、《第四军医大学学报》编委。被评为解放军总后勤部科技新星、银星,获国家教育部高等学校骨干教师资助计划资助和政府特殊津贴。长期从事分子发育生物学的基础和医学相关研究,在Notch信号通路的研究中获得了有重要创新价值的研究成果。建立了多种Notch相关的基因剔除小鼠模型,证明了Notch信号途径在淋巴细胞分化、造血、血管内皮细胞分化以及干细胞增殖分化中的多种重要作用,并深入探讨了相应的分子机理。近年来承担国家杰出青年科学基金项目、国家自然科学基金重点项目、教育部跨世纪优秀人才基金项目等10余项课题。获陕西省科技一等奖1项,获中华医学科技三等奖1项。在包括《自然免疫学》、《核酸研究》、《生物化学杂志》等在内的国际SCI检索杂志发表学术论文30余篇,被引用280余次,参编学术著作7部。

代表性论文:

1、Guo-Rui Dou, Yao-Chun Wang, Xing-Bin Hu, Li-Hong Hou, Chun-Mei Wang, Jian-Feng Xu, Yu-Sheng Wang, Ying-Min Liang, Li-Bo Yao, An-Gang Yang,Hua HanCA. RBP-J, the transcription factor downstream of Notch receptors, is essential for the maintenance of vascular homeostasis in adult mice.FASEB J.Epub ahead of print.

2、Jishu Wang,Hongyan Qin,Jie Liang,Yangting Zhu,Liang Liang, Minhua Zheng, andHua HanCA. The transcriptional repression activity of KyoT2 on the Notch/RBP-J pathway is regulated by PIAS1-catalyzed SUMOylation.J. Mol. Biol.2007; 370:27-38.

3、WeiLi, MengFu, JingangAn, YingXing, PingZhang, XinZhang, YaochunWang, ChengxinLi, RongTian, WenjingSu, HaihongGuan, GangWang, TianwenGao,HuaHanCA, and YufengLiu.Host defense againstC. albicansinfections in IgH transgenic mice with VHderived from a natural anti-keratin antibody.Cell. Microbiol.2007; 9:306-315.

4、Ping Zhang, Wei Li, Yaochun Wang, Lihong Hou, Ying Xing, Hongyan Qin, Jishu Wang, Yingmin Liang, andHua HanCA. Identification of CD36 as a new surface marker of marginal zone B cells by transcriptomic analysis.Mol. Immunol.2007; 42:332-337.

5、Xi Yang, Junfeng Li, Hongyan Qin, Hui Yang, Junlin Li, Peng Zhou, Yingmin Liang, andHua HanCA. Mint represses transactivation of the type II collagen gene enhancer through interaction with aA -crystallin-binding protein 1.J. Biol. Chem.2005;280:18710-18716.

6、Hongyan Qin, Jishu Wang, Yingmin Liang, Yoshihito Taniguchi, Kenji Tanigaki, andHua HanCA. RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2.Nucleic Acids Res.2004; 32:1492-1501.

7、Kenji Tanigaki, Masayaki Tsuji, Norio Yamamoto,Hua Han§, Jun Tsukada, Hiromasa Inoue, Masato Kubo, and Tasuku Honjo. Regulation ofab/gdT cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.Immunity2004;20:611-622. (§co-first author)

8、Kazuki Kuroda,Hua Han§, Shoichi Tani, Kenji Tanigaki, Tin Tun, Takahisa Furukawa, Yoshihito Taniguchi, Hisanori Kurooka, Yoshio Hamada, Shinya Toyokuni, and Tasuku Honjo. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.Immunity2003; 18:301-312. (§co-first author)

9、Kenji Tanigaki,Hua Han§, Norio Yamamoto, Kei Tashiro, Masaya Ikegawa, Kazuki Kuroda, Akira Suzuki, Toru Nakano, and Tasuku Honjo. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.Nat. Immunol.2002; 3:443-450. (§co-first author)


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