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教研室发表论文目录


更新时间:2014-05-16



1.Ming-Hui Zhu, Wen-Bo Dong, Guang-Ying Dong,Ping Zhang, Yong-Jin Chen, Bu-Ling Wu, Hua Han. Disturbed tooth germ development in the absence of MINT in the cultured mouse mandibular explants.Mol Biol Rep (2011) 38:777–784

2.Jian-Ping Zhang, Hong-Yan Qin, Li Wang, Liang Liang , Xing-Cheng Zhao ,Wei-Xia Cai, Ya-Ning Wei, Chun-Mei Wang, Hua Han. Overexpression of Notch ligand Dll1 in B16 melanoma cells leads to reduced tumor growth due to attenuated vascularization.Cancer Letters 309 (2011) 220–227

3.Yi-Yang Hu, Min-Hua Zheng, Gang Cheng, Liang Li, Liang Liang, Fang Gao, Ya-Ning Wei, Luo-An Fu,Hua Han. Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells.Hu et al. BMC Cancer 2011, 11:82.

4.Tao Fu, Ping Zhang, Lei Feng, Gang Ji, Xiao-HongWang, Min-Hua Zheng,Hong-Yan Qina, Dong-Li Chen,Wei-Zhong Wang, Hua Han. Accelerated acute allograft rejection accompanied by enhanced T-cell proliferation and attenuated Treg function in RBP-J deficient mice.Molecular Immunology 48 (2011) 751–759

5.Minhua Zheng, Zifeng Zhang, Xingcheng Zhao, Yuqiang Ding, Hua Han. The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis. J. Genet. Genomics 37 (2010) 573−582

6.Xingcheng Zhao , Ping Zhang , Qiang Liu ,Fei He , Lei Feng , Hua Han.Expression, purification and characterization of the extracellular domain of human Flt3 ligand in Escherichia coli.Mol Biol Rep (2010)37:2301–2307

7.Yao-Chun Wang, Fei He, Fan Feng, Xiao-Wei Liu, Guang-Ying Dong, Hong-Yan Qin, Xing-Bin Hu,Min-Hua Zheng,Liang Liang, Lei Feng, Ying-Min Liang, and Hua Han.Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses.Cancer Res; 70(12) June 15, 2010

8.Guo-Hui Li, Yu-Zhen Fan, Xiao-Wei Liu, Bing-Fang Zhang, Dan-Dan Yin, Fei He, Si-Yong Huang, Zhi-Jie Kang, Heng Xu, Qiang Liu ,Yan-Lan Wu ,Xiao-Li Niu, Li Zhang, Li Liu, Miao-Wang Hao, Hua Han , Ying-Min Liang. Notch signaling maintains proliferation and survival of the HL60 human promyelocytic leukemia cell line and promotes the phosphorylation of the Rb protein. Mol Cell Biochem (2010) 340:7–14

9.Fan Feng, Yao-Chun Wang, Xing-Bin Hu, Xiao-Wei Liu, Gang Ji, Yun-Ru Chen, Lin Wang, Fei He, Guo-Rui Dou,Liang Liang, Hong-Wei Zhang and Hua Han. The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice. Molecular Cancer 2010, 9:90

10. Fang Gao, Qi Zhang, MinHua Zheng, HuiLing Liu, YiYang Hu, Ping Zhang, ZhengPing Zhang, HongYan Qin, Lei Feng, Li Wang, Hua HanCA and Gong Ju. Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors. Mol Cell Neurosci. 2009

11. Ying Xing, Wei Li, Ying Lin, Meng Fua, Cheng-xin Li, Ping Zhang, Liang Liang, GangWang, Tian-wen Gao, Hua Han.CA, Yu-feng Liua. The influence of BCR density on the differentiation of natural poly-reactive B cells begins at an early stage of B cell development. Molecular Immunology. 2009; 46: 1120–1128

12. XingBin Hu, Fan Feng, YaoChun Wang, Lin Wang, Fei He, GuoRui Dou, Liang Liang, HongWei Zhang, YingMin Liang, Hua HanCA. Blockade of Notch Signaling in Tumor-Bearing Mice May Lead to Tumor Regression, Progression, or Metastasis, Depending on Tumor Cell Types1. Neoplasia. 2009;11:32-8. (IF=5.674)

13. Lin Wang, ChunMei Wang, LiHong Hou, GuoRui Dou, YaoChun Wang, Xing-Bin Hu, Fei He, Fan Feng, HongWei Zhang, YingMin Liang, KeFeng Dou, Hua HanCA. Veno-occlusive disease and abnormal liver regeneration occur with disruption recombination signal-binding protein (RBP) in mice. Hepatology 2009;49 :268-77. (IF=10.734)

14. DanDan Yin, FengYun Fan, XingBin Hub, LiHong Hou, XuePing Zhang , Li Liua, YingMin Liang,Hua HanCA.. Notch signaling inhibits the growth of the human chronic myeloid leukemia cell line K562. Leukemia Research. In press.

15. Fei He, Li Wang, XingBin Hu, DanDan Yin, Ping Zhang, GuoHui Li, YaoChun Wang, SiYong Huang, YingMin Liang, Hua Han*. Notch and BCR signaling synergistically promote the proliferation of Raji B-lymphoma cells. Leukemia Research. In press.

16. Liang Liang, Hong-Wei Zhang, Jie Liang, XiaoLi Niu, SuZhen Zhang, Lei Feng, YingMin Liang, Hua HanCA.KyoT3, an isoform of murine FHL1, associates with the transcription factor RBP-J and represses the RBP-J-mediated transactivation. Biochemica et Biophysica Acta. In press.

17. HaiFeng OuYang, HongWei Zhang, ChangGui Wu, Ping Zhang, Jian Zhang, JunChang Li, LiHong Hou, Fei He, XinYu Ti, LiQiang Song, SuZhen Zhang, Lei Feng, HaoWen Qi, Hua HanCA.Notch signaling regulates the FOXP3 promoter through RBP-J-and Hes1-dependent mechanisms. Mol. Cell. Biochem. In Press.

18. Zhan-Xia Shi, Fei He, Li-Li Wang, Ying-Min Liang, Hua HanCA, Chao-Zhan Wang, Qun Zhao, Xin-Du Geng. Expression, refolding, and purification of a truncated human Delta-like1, a ligand of Notch receptors. Protein Expr. Purif. 2008;59:242-248

19. Guo-Rui Dou, Yao-Chun Wang, Xing-Bin Hu, Li-Hong Hou, Chun-Mei Wang, Jian-Feng Xu, Yu-Sheng Wang, Ying-Min Liang, Li-Bo Yao, An-Gang Yang, Hua HanCA. RBP-J, the transcription factor downstream of Notch receptors, is essential for the maintenance of vascular homeostasis in adult mice. FASEB J. 2008; 22:1606-1617.

20. Xue-Ping Zhang, Gang Zheng, Lian Zou, Hui-Ling Liu, Li-Hong Hou, Peng Zhou, Dan-Dan Yin, Qi-Jun Zheng,Liang Liang, Su-Zhen Zhang, Lei Feng, Li-Bo Yao, An-Gang Yang, Hua HanCA, Jing-Yuan Chen. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. Mol. Cell. Biochem. 2008; 307:101-108.

21. Jishu Wang,Hongyan Qin, Jie Liang, Yangting Zhu, Liang Liang, Minhua Zheng, Hua HanCA. The transcriptional repression activity of KyoT2 on the Notch/RBP-J pathway is regulated by PIAS1-catalyzed SUMOylation. J. Mol. Biol.2007; 370:27-38.

22. Qijun Zheng, Hongyan Qin, Hongwei Zhang, Junchang Li, Lihong Hou, Hongbin Wang, Xueping Zhang, Suzhen Zhang, Lei Feng, Yingmin Liang, Hua HanCA, and Dinghua Yi. Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549. Oncol. Reports. 2007; 17:847-852.

23. Wei Li, Meng Fu, Jingang An, Ying Xing, Ping Zhang, Xin Zhang, Yaochun Wang, Chengxin Li, Rong Tian, Wenjing Su, Haihong Guan, Gang Wang, Tianwen Gao, Hua HanCA, and Yufeng Liu.Host defense against C. albicans infections in IgH transgenic mice with VH derived from a natural anti-keratin antibody. Cell. Microbiol. 2007;9:306-315.

24. Ping Zhang, Wei Li, Yaochun Wang, Lihong Hou, Ying Xing, Hongyan Qin, Jishu Wang, Yingmin Liang, and Hua HanCA. Identification of CD36 as a new surface marker of marginal zone B cells by transcriptomic analysis. Mol.Immunol. 2007; 42:332-337.

25. Junfeng Li, Jishu Wang, Xi Yang, Junlin Li, Hongyan Qin, Xiao Dong, Yangting Zhu, Liang Liang, Yingmin Liang, Hua HanCA. The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8. Mol. Cell. Biochem. 2006; 288:151-157.

26. Yaochun Wang, Ping Zhang, Wei Li, Lihong Hou, Jishu Wang, Yingmin Liang, and Hua HanCA. Mouse follicular and marginal zone B cells show differential expression of Dnmt3a and sensitivity to 5’-azacytidine. Immunol. Lett. 2006; 105:174-179.

27. Mariko Moriyama, Masatake Osawa, Siu-Shan Mak, Toshiyuki Ohtsuka, Norio Yamamoto, Hua Han, Veronique Delmas, Ryoichiro Kageyama, Friedrich Beermann, Lionel Larue, Shin-ichi Nishikawa. Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J. Cell Biol. 2006; 173:333-339.

28. Xi Yang, Junfeng Li, Hongyan Qin, Hui Yang, Junlin Li, Peng Zhou, Yingmin Liang, and Hua HanCA. Mint represses transactivation of the type II collagen gene enhancer through interaction with aA -crystallin-binding protein 1. J. Biol. Chem.2005; 280:18710-18716.

29. Junlin Li, Junfeng Li, Xi Yang, Hongyan Qin, Peng Zhou,Yingmin Liang, Hua HanCA. The C terminus of MINT forms homodimers and abrogates MINT-mediated transcriptional repression. Biochim Biophys. Acta. 2005; 1279:50-56.

30. Qi Zhang, Hongyan Qin, Bing Lang, Huiling Liu, Hua HanCA, and Gong Ju. Different regions of the mouse nestin enhancer may function differentially in nestin expression in an NSC-like cell line and astrocytes. Neurosci. Lett. 2005; 379:90-95.

31. Hongyan Qin, Dewei Du, Yangting Zhu, Junfeng Li, Lei Feng, Yingmin Liang, and Hua HanCA. The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2. FEBS Lett. 2005; 579:1220-1226.

32. Qiang Sun, Jiang Li, Chunmei Wang, Xiaofeng Huang, Hongyan Huang, Dewei Du, Yingmin Liang, and Hua HanCA.Overexpression of mouse GlcNAc-1-phosphotransferase-γ subunit in cells induced an I-cell-like phenotype of mucolipidosis. Gene. 2005; 347:55-64.

33. Hongyan Qin, Jishu Wang, Yingmin Liang, Yoshihito Taniguchi, Kenji Tanigaki and Hua HanCA. RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2. Nucleic Acids Res. 2004; 32:1492-1501.

34. Kenji Tanigaki, Masayaki Tsuji, Norio Yamamoto, Hua Han*, Jun Tsukada, Hiromasa Inoue, Masato Kubo and Tasuku Honjo. Regulation of ab/gd T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 2004; 20:611-622. (*co-first author)

35. Norio Yamamoto, Kenji Tanigaki, Hua Han*, Hiroshi Hiai and Tasuku Honjo. Notch/RBP-J signaling regulates Epidermis/Hair fate determination of hair follicular stem cells. Curr. Biol. 2003; 13:333-338. (*co-first author)

36. Kazuki Kuroda, Hua Han*, Shoichi Tani, Kenji Tanigaki, Tin Tun, Takahisa Furukawa, Yoshihito Taniguchi, Hisanori Kurooka, Yoshio Hamada, Shinya Toyokuni and Tasuku Honjo. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 2003; 18:301-312. (*co-first author)

37. Kenji Tanigaki, Kazuki Kuroda, Hua Han, Tasuku Honjo. Regulation of B cell development by Notch/RBP-J signaling. Semin. Immunol. 2003; 15:113-119.

38. Yanchun Deng, Libo Yao, Ling Chau, Samuel Sai-ming Ng, Ying Peng, Xinping Liu, Wo-shing Au, Jicun Wang, Fuyang Li, Shaoping Ji, Hua Han, Xiaoyan Nie, Qing Li, Hsiang-fu Kung, Suet-yi Leung, Marie Chia-mi Lin. N-Mycdownstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Int. J. Cancer. 2003; 106:342-347.

39. Kenji Tanigaki, Hua Han*, Norio Yamamoto, Kei Tashiro, Masaya Ikegawa, Kazuki Kuroda, Akira Suzuki, Toru Nakano and Tasuku Honjo. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat. Immunol. 2002; 3:443-450. (*co-first author)

40. Hua Han, Kenji Tanigaki, Norio Yamamoto, Kazuki Kuroda, Momoko Yoshimoto, Tatsutoshi Nakahata, Koichi Ikuta and Tasuku Honjo. RBP-J deficient mouse reveals essential role of Notch in T versus B lineage determination but not in later stages of thymocyte development. Int. Immunol. 2002; 14:637-645. 41. Jishu Wang, Xi Yang, Rong Li, Peng Zhou, Hua HanCA. Cloning of mouse genomic ribosomal protein L6 gene and analysis of its promoter. Biochem. Biophys. Acta 2002; 1576:219-224.

42. Shoichi Tani, Masafumi Taniwaki, Yoshihito Taniguchi, Shigeru Minoguchi, Kazuki Kuroda, Hua Han, Tomokazu Aoki, Shin-ichi Miyatake, Nobuo Hashimoto and Tasuku Honjo. Chromosome mapping of two RBP-J-related genes: Kyo-T and RBP-L. J. Hum. Genet.1999; 44:73-75

43. Yoshihito Taniguchi, Tokuhisa Turukawa, Tin Tun, Hua Han and Tasuku Honjo. LIM protein KyoT2 negatively regulates transcription by association with RBP-J DNA-binding protein. Mol. Cell. Biol. 1998; 18:644-654.

44. Hua Han, Takashi Nomura, Tasuku Honjo and Takeshi Tsubata. Involvement of the cyclin-dependent kinase inhibitor p27Kip1 in negative signaling through the antigen-receptor of B lymphocytes. Leukemia.1997; 11(Supp3):367-369.

45. Michael B Paumen, Yasumasa Ishida, Hua Han, Masamichi Muramatsu, Yutaka Eguchi, Yoshihide Tsujimoto and Tasuku Honjo. Direct interaction of the mitochondrial protein carnitine palmitoyltransferase I and Bcl-2. Biochem. Biophysics Res. Com. 1997; 31: 523-525.

46. Takashi Nomura, Hua Han, Maureen C. Howard, Hideo Yagita, Hidetaka Yakura, Tasuku Honjo and Takeshi Tsubata. Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice. In. Immunol. 1996; 6:867-875.

47. Hua Han, Takashi Nomura, Tasuku Honjo and Takeshi Tsubata. Differential modulation of cyclin-dependent kinase inhibitor p27kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40. Eur. J. Immunol. 1996; 26:2425-2432.

48. Akira Shimizu, Michel C. Nussenzweig, Hua Han, Mercedes Sanchez and Tasuku Honjo. Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobin gene. J. Exp. Med. 1991;173:1385-1393.

49. Hua Han, Masaya Okamoto, Tasuku Honjo, Akira Shimizu. Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of a transgenic m chain and constant regions of endogenous isotype. Int. Immunol. 1991; 3:1197-1206.


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