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胡昳旸讲师


更新时间:2014-05-29



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胡昳旸女,1984年4月出生,研究生期间一直从事Notch信号通路与胶质瘤干细胞相关机制的研究,并参与多个国家自然科学基金的研究工作,博士课题为“Notch信号通路对胶质瘤干细胞作用的研究”。2002/09-2006/06,江西中医学院大学本科生物工程专业,学士。2006/09-2012/06,第四军医大学发育生物学专业,硕博连读研究生,导师韩骅教授,博士。2012/06至今基础部医学遗传与发育生物学教研室助教。

科研成果

1.Hu YY, Fu LA, Li SZ, Chen Y, Li JC, Han J, Liang L, Li L, Ji CC, Zheng MH, Han H*. Hif-1α and Hif-2α differentially regulate Notch signaling through competitive interaction with the intracellular domain of Notch receptors in glioma stem cells. Cancer Letters. .accepted

2.Li SZ,Hu YY, Zhao J, Zhao YB, Sun JD, Yang YF, Ji CC, Liu ZB, Cao WD, Qu Y, Liu WP, Cheng G, Fei Z*.MicroRNA-34a induces apoptosis in the human glioma cell line, A172, through enhanced ROS production and NOX2 expression. Biochem Biophys Res Commun. 444(1):6-12.2014(共同第一作者)

3. Ma J, Liu YL,Hu YY, Wei YN, Zhao XC, Dong GY, Qin HY, Ding Y, Han H. Hong-Yan Qin, Yin Ding and Han H*. Disruption of the transcription factor RBP-J results in osteopenia attributable to attenuated osteoclast differentiation. Mol Biol Rep. 40(3):2097-105 2013 (共同第一作者)

4.Hu YY, Zheng MH, Zhang R, Liang YM, Han H.*. Notch Signaling Pathway and Cancer Metastasis. Adv Exp Med Biol727:186-98. 2012;

5.Hu YY, Zheng MH, Cheng G, Li L, Liang L, Gao F, Wei YN, Fu LA, Han H*. Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells. BMC Cancer 11:82-94 2011

6.Zheng MH,Hu YY,Fu LAandHan H*. Regulation of Cancer Stem Cells by the Notch Signaling Pathway: Basic Mechanisms and Clinical Implications.

In“Cancer stem cells”,edited by culumbus F., Novascience publishers.ISBN: 978-1-61668-971-1. 2010 (共同第一作者)

7.Gao F, Zhang Q, Zheng MH, Liu HL,Hu YY, Zhang P, Zhang ZP, Qin HY, Feng L,Wang L, Han H, Ju G*. Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors. Molecular and Cellular Neuroscience 40(4):442-50.2009


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