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秦鸿雁教授


更新时间:2014-05-16



秦鸿雁,空军军医大学(原第四军医大学)基础医学院遗传学与发育生物学教研室主任、教授,博士生导师,肿瘤生物学国家重点实验室肿瘤细胞分化研究单元骨干成员。现任陕西省遗传学会第八届理事会副理事长(2017),陕西省医学会医学遗传学分会委员会委员(2016)和全军医学科委会转化医学专业委员会委员(2015)。入选陕西省中青年科技创新领军人才。荣获陕西省青年科技奖和军队育才银奖。主要研究方向为单核-巨噬细胞在炎-癌转化中的作用和机制研究。先后负责和承担国家自然科学基金含重点项目7项,军队面上项目2项,973课题子项目1项。作为项目骨干负责国家重点研发计划精准医学研究重点专项项目子课题1项。发表SCI论文39篇,其中以第一/通讯(含共同)作者14篇。IF大于10的4篇。代表性论文发表在Hepatology、J Hepatol、Cancer Res等国际知名期刊。获国家发明专利授权1项。主、参编中英文专著7部。研究成果获国家科学技术进步二等奖1项(第9)和陕西省科学技术奖一等奖 2项(第2和第4)。

代表性论著:

1. He F, Guo FC, Li Z, Yu HC, Ma PF, Zhao JL, Feng L, Li WN, Liu XW,Qin HY*, Dou KF*, Han H*. Myeloid-specific disruption of RBP-J ameliorates hepatic fibrosis by attenuating inflammation through cylindromatosis in mice. Hepatology. 61(1): 303-314. 2015. (Co-corresponding author)(IF=11.19)

2. Zhao JL, Liang SQ, Fu W, Zhu BK, Li SZ, Han H,Qin HY. The LIM domain protein FHL1C interacts with tight junction protein ZO-1 contributing to the epithelial-mesenchymal transition (EMT) of a breast adenocarcinoma cell line. Gene. 542(2): 182-9. 2014 (Corresponding author)(IF=2.119)

3. Fu W, Wang K, Zhao JL, Yu HC, Li SZ, Lin Y, Liang L, Huang SY, Liang YM, Han H,Qin HY. FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J. BMC Cancer.14(1): 463-476. 2014 (Corresponding author)(IF=3.333)

4.Qin HY, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong le T, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H. Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age. Plos One. 6(12):e29141. 2011.(IF=4.411)

5.Qin HY, Wang JS, Liang YM, Taniguchi Y, Tanigaki K, Han H. RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2. Nucleic Acids Res., 2004; 32(4):1492-1501.(IF=7.260)

6.Qin HY, Du DW, Zhu YT, Li JF Feng L Liang YM Han H. The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2. FEBS Letters, 2005, 579(5): 1220-1226.(IF=3.415)

7. Yu HC,Qin HY*, He F, Wang L, Fu W, Liu D, Guo FC, Liang L, Dou KF, Han H. Canonical Notch pathway protects hepatocytes from ischemia reperfusion injury by repressing ROS production through JAK2/STAT3 signaling. Hepatology, 2011,54:979-988. (Co-first author)(IF=10.885)

8. Zhang JP,Qin HY*, Wang L, Liang L, Zhao XC, Cai WX, Wei YN, Wang CM, Han H. Overexpression of Notch ligand Dll1 in B16 melanoma cells leads to reduced tumor growth due to attenuated vascularation. Cancer Lett, 2011, 309(2):220-227.(Co-first author)(IF=4.864)

9. Wang JS,Qin HY*, Liang J, Zhu YT, Liang L, Zheng MH, Han H. The transcriptional repression activity of KyoT2 on the Notch/RBP-J pathway is regulated by PIAS1-catalyzed SUMOylation.J Mol Biol., 2007; 370(1): 27-38. (Co-first author)(IF=4.89)

10. Zheng QJ,Qin HY*, Zhang HW, Li JC, Hou LH, Wang HB, Zhang XP, Zhang SZ, Feng L, Liang YM, Han H, Yi DH. Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549. Oncol Rep. 2007 Apr; 17(4):847-52. (co-first author)(IF=1.567)


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