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胶质瘤细胞和Notch信号途径


更新时间:2011-12-23



Introduction

Glioma is the most common malignant tumor of the central nervous system (CNS)

following with high fatality. A large body of evidence has been accumulated showing that

a group of neural stem cell (NSC)-like tumor cells in glioma, or glioma stem cells (GSCs),

play a critical role in the initiation and the progression of glioma. The Notch signaling

pathway is a highly conserved pathway maintaining stem cell state and governing the

differentiation of NSCs. Several research groups, including ours, have recently shown

that Notch signaling is also critically involved in the maintenance of GSCs. Most

impressively, blocking Notch signaling appears to result in the exhaustion of GSCs in

animal models, leading to the proposition that the Notch signaling pathway might be a

potential therapeutic target of glioma. In this review, we will briefly introduce the concepts

of cancer stem cells (CSCs) and GSCs, followed by a summary of the cellular and molecular

properties so far uncovered about GCSs. We will then discuss the major progresses about

the roles and mechanisms of Notch signaling in the proliferation, differentiation, and

apoptosis of GSCs, in addition to the function of Notch signaling in tumor

microenvironment especially stem cell niches. Finally, we will prospect the application of

Notch signaling as a therapeutic target of glioma, emphasizing its potential advantages and

disadvantages.

具体内容请参考:http://dl.dbank.com/c0bwd8byy5


上一条:M-H Zhu等Mol Biol Rep (2011)
下一条:MH-Zheng (BioMed  Central)2009

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